The entry list for the 105th running of the Indianapolis 500 has 35 drivers on it, 33 of those drivers will compete in the race on May 30.
Included in the field are nine former winners. Three-time winner Helio Castroneves (2001, 2002, 2009), two-time winners Juan Pablo Montoya (2000, 2015) and Takuma Sato (2017, 2020), plus single winners Scott Dixon (2008), Tony Kanaan (2013), Ryan Hunter-Reay (2014), Alexander Rossi (2016), Will Power (2018) and Simon Pagenaud (2019).
Scott McLaughlin, Pietro Fittipaldi, and RC Enerson make up the rookies on the entry list. Simona De Silvestro, who last competed in the 500 in 2015, is the lone woman attempting to make the race.
Chevrolet makes up 18 entries, while Honda is the remaining 17. All cars in the series use the Dallara chassis and Firestone tires. Practice at the 2.5-mile track begins on May 18 and runs until qualifying which will be held May 22-23.
Indianapolis 500 entry list:
| No. | Driver | Team | Engine | |
| 1 | 1 | JR Hildebrand | A.J. Foyt Enterprises | Chevrolet |
| 2 | 2 | Josef Newgarden | Team Penske | Chevrolet |
| 3 | 3 | Scott McLaughlin (R) | Team Penske | Chevrolet |
| 4 | 4 | Dalton Kellett | A.J. Foyt Enterprises | Chevrolet |
| 5 | 5 | Pato O’Ward | Arrow McLaren SP | Chevrolet |
| 6 | 06 | Helio Castroneves (W) | Meyer Shank Racing | Honda |
| 7 | 7 | Felix Rosenqvist | Arrow McLaren SP | Chevrolet |
| 8 | 8 | Marcus Ericsson | Chip Ganassi Racing | Honda |
| 9 | 9 | Scott Dixon (W) | Chip Ganassi Racing | Honda |
| 10 | 10 | Alex Palou | Chip Ganassi Racing | Honda |
| 11 | 11 | Charlie Kimball | A.J. Foyt Enterprises | Chevrolet |
| 12 | 12 | Will Power (W) | Team Penske | Chevrolet |
| 13 | 14 | Sebastien Bourdais | A.J. Foyt Enterprises | Chevrolet |
| 14 | 15 | Graham Rahal | Rahal Letterman Lanigan Racing | Honda |
| 15 | 16 | Simon De Silvestro | Paretta Autosport | Chevrolet |
| 16 | 18 | Ed Jones | Dale Coyne Racing with Vasser Sullivan | Honda |
| 17 | 20 | Ed Carpenter | Ed Carpenter Racing | Chevrolet |
| 18 | 21 | Rinus VeeKay | Ed Carpenter Racing | Chevrolet |
| 19 | 22 | Simon Pagenaud (W) | Team Penske | Chevrolet |
| 20 | 24 | Sage Karam | Dreyer & Reinbold Racing | Chevrolet |
| 21 | 25 | Stefan Wilson | Andretti Autosport | Honda |
| 22 | 26 | Colton Herta | Andretti Autosport w/ Curb-Agajanian | Honda |
| 23 | 27 | Alexander Rossi (W) | Andretti Autosport | Honda |
| 24 | 28 | Ryan Hunter-Reay (W) | Andretti Autosport | Honda |
| 25 | 29 | James Hinchcliffe | Andretti Steinbrenner Autosport | Honda |
| 26 | 30 | Takuma Sato (W) | Rahal Letterman Lanigan Racing | Honda |
| 27 | 45 | Santino Ferrucci | Rahal Letterman Lanigan Racing | Honda |
| 28 | 47 | Conor Daly | Ed Carpenter Racing | Chevrolet |
| 29 | 48 | Tony Kanaan (W) | Chip Ganassi Racing | Honda |
| 30 | 51 | Pietro Fittipaldi (R) | Dale Coyne Racing/RWR | Honda |
| 31 | 59 | Max Chilton | Carlin | Chevrolet |
| 32 | 60 | Jack Harvey | Meyer Shank Racing | Honda |
| 33 | 75 | RC Enerson (R) | Top Gun Racing | Chevrolet |
| 34 | 86 | Juan Pablo Montoya (W) | Arrow McLaren SP | Chevrolet |
| 35 | 98 | Marco Andretti | Andretti Herta-Haupert with Marco & Curb-Agajanian | Honda |
