Below you can find the start times and probable pitchers for Major League Baseball games from Wednesday May 21, 2014.
| Starts | Visitors | Home |
| 12:05 PM ET | DET – Max Scherzer (6-1, 1.83) | CLE – Zach McAllister (3-4, 5.36) |
| 2:05 PM ET | SEA – Chris Young (3-1, 3.22) | TEX – Nick Tepesch (0-0, 1.69) |
| 2:20 PM ET | NYY – Chase Whitley (0-0, 0.00) | CHC – Jeff Samardzija (0-4, 1.62) |
| 4:05 PM ET | CIN – Alfredo Simon (5-2, 2.45) | WAS – Tanner Roark (3-1, 3.65) |
| 7:05 PM ET | BAL – Chris Tillman (4-2, 3.34) | PIT – Wandy Rodriguez (0-2, 6.84) |
| 7:10 PM ET | TOR – Drew Hutchison (2-3, 3.64) | BOS – Clay Buchholz (2-3, 6.17) |
| 7:10 PM ET | MIL – Kyle Lohse (5-1, 2.88) | ATL – Ervin Santana (4-1, 2.76) |
| 7:10 PM ET | LAD – Hyun-jin Ryu (3-2, 3.00) | NYM – Jacob deGrom (0-1, 1.29) |
| 7:10 PM ET | PHI – Kyle Kendrick (0-4, 3.96) | MIA – Nathan Eovaldi (2-2, 3.62) |
| 7:10 PM ET | OAK – Tommy Milone (1-3, 4.10) | TB – Erik Bedard (2-1, 2.78) |
| 8:10 PM ET | CWS – Jose Quintana (2-3, 3.67) | KC – Jeremy Guthrie (2-3, 4.76) |
| 8:15 PM ET | ARI – Brandon McCarthy (1-6, 5.01) | STL – Michael Wacha (3-3, 2.82) |
| 8:40 PM ET | SF – Matt Cain (1-3, 4.33) | COL – Jhoulys Chacin (0-2, 4.76) |
| 10:05 PM ET | HOU – Collin McHugh (2-2, 3.48) | LAA – Jered Weaver (4-3, 3.14) |
| 10:10 PM ET | MIN – Phil Hughes (4-1, 3.61) | SD – Tyson Ross (5-3, 2.81) |
