Arizona Cardinals versus San Francisco 49ers point spread, line and betting odds


The Arizona Cardinals will visit the San Francisco 49ers in Week 17. FOX will carry this game which has a 4:25 pm EST kickoff.

San Francisco will look to win their second consecutive NFC West title against a team which has never found the right quarterback.

What is the point spread in the 49ers and Cardinals game? The 49ers are 16.5 point favorites against the Cardinals. The over/under for this game is 39 points.

W-L 5-10 10-4-1
Avg Points 15.8 24.7
Avg Points Allowed 22.0 17.3
Home Record 4-4 5-1-1
Road Record 1-6 5-3

The 49ers are coming off a stinging loss the Seattle. They need a win or a Seahawks loss to win the division. The 49ers are also no longer in the drivers seat for a first round bye. Defensive lineman Justin Smith had made 185 straight starts until last week. He will also miss this game. The 49ers will also be without Mario Manningham and could be without Vernon Davis.\

Even with all the injuries and problems with the 49ers they are expected to crush Arizona. The Cardinals will give Brian Hoyer the start in this game. He saw mop-up duty in last weeks game after Ryan Lindley struggled again. After starting the season 4-0 the Cardinals have lost ten of their last eleven.